Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic
metabolism, either as a consequence or as a cause. As an example, the resistance of …

The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs).
However, the metabolic requirements that support this process remain poorly defined. We …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …