Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

Group A streptococci are model extracellular gram-positive pathogens responsible for
pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of …

Streptococcus pyogenes is an important human pathogen that selectively interacts with
proteins involved in the humoral defense system, such as immunoglobulins and …

Objective. To determine the most effective antibiotic treatment for invasive S. pyogenes
infection in humans. Design and setting. We conducted a retrospective review of the …

Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and
intriguing conditions in the discipline of pediatric nephrology. Although the eventual …

Multilocus sequence ty** (MLST) is a tool that can be used to study the molecular
epidemiology and population genetic structure of microorganisms. A MLST scheme was …

Although nitric oxide (NO) kills or inhibits the replication of a variety of intracellular
pathogens, the antimicrobial mechanisms of NO are unknown. Here, we identify a viral …

Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that
causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to …

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as
well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades …

The ability of numerous microorganisms to cause disease relies upon the highly regulated
expression of secreted proteinases. In this study, mutagenesis with a novel derivative of …