Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Non-protein-coding transcripts have been conserved throughout evolution, indicating that
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …

Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy
requirements for this expansion are formidable, and T‐cell activation is accompanied by …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …

Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA
polymerase-II-based transcription and promotes tumor progression. However, the …

Abstract mTORC2 is a multimeric kinase composed of the mammalian target of rapamycin
kinase (mTOR), mLST8, mSin1, and rictor. The complex is insensitive to acute rapamycin …

Progression through the stages of lymphocyte development requires coordination of the cell
cycle. Such coordination ensures genomic integrity while cells somatically rearrange their …

A gene expression signature of tumor proliferation rate in mantle cell lymphoma (MCL) is an
overriding molecular predictor of the length of survival following diagnosis. Many strongly …

Tristetraprolin (TTP) is an RNA-binding protein required for the rapid degradation of mRNAs
containing AU-rich elements. Targets regulated by TTP include the mRNAs encoding tumor …