One of the great strengths of the mouse model is the wide array of genetic tools that have
been developed. Striking examples include methods for directed modification of the …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

One of the primary challenges of our time is to enhance global food production and security.
Most assessments in agricultural systems focus on plant yield. Yet, these analyses neglect …

The health benefits of chronic caloric restriction resulting in lifespan extension are well
established in many short-lived species, but the effects in humans and other primates …

Patterns of individual differences in cognition have been studied empirically and
systematically in the last decade, but causes and consequences of this variation are still …

Since the description by Alois Alzheimer, more than 50 years have passed during which
senile dementia and pre-senile dementia have been considered Alzheimer disease (AD) on …

Torpor and hibernation are powerful strategies enabling animals to survive periods of low
resource availability. The state of torpor results from an active and drastic reduction of an …

The health benefits of chronic caloric restriction (CR) resulting in lifespan extension are well
established in many species and has been recently demonstrated also in non-human …

DNA methylation‐based biomarkers of ageing (epigenetic clocks) promise to lead to new
insights into evolutionary biology of ageing. Relatively little is known about how the natural …

Animal disease models are considered important in the development of drugs for
Alzheimer's disease. This brief review will discuss possible reasons why their success in …