Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Oxidative stress in oocyte aging and female reproduction
L Wang, J Tang, L Wang, F Tan, H Song… - Journal of cellular …, 2021 - Wiley Online Library
In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …
[HTML][HTML] Genome-wide methylation profiles reveal quantitative views of human aging rates
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …
many fields, including disease prevention and treatment, forensics, and extension of life …
[HTML][HTML] Cellular senescence in cancer and aging
Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple
mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF …
mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
Association of telomere length with risk of disease and mortality
Importance Telomeres protect DNA from damage. Because they shorten with each mitotic
cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been …
cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been …
Obesity accelerates epigenetic aging of human liver
S Horvath, W Erhart, M Brosch… - Proceedings of the …, 2014 - National Acad Sciences
Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …
Telomerase mutations in families with idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial
clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR …
clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR …
The impact of oxidative DNA damage and stress on telomere homeostasis
Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …
chromosome ends. Because telomeres shorten progressively with each replication, they …