Heart failure is a major cause of death and disability. Impairments in blood circulation that
accompany heart failure can be traced, in part, to alterations in the activity of the …

P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably
simple with only a single catalytic subunit and carry out large domain motions during …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Micropeptides function as master regulators of calcium-dependent signaling in muscle.
Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), the membrane pump that promotes …

P-type ATPases are ion pumps that carry out many fundamental processes in biology and
medicine, ranging from the generation of membrane potential to muscle contraction and the …

Sodium–potassium ATPase is an ATP-powered ion pump that establishes concentration
gradients for Na+ and K+ ions across the plasma membrane in all animal cells by pum** …

Abnormalities of diastolic function are common to virtually all forms of cardiac failure.
However, their underlying mechanisms, precise role in the generation and phenotypic …

The sarcoplasmic (SERCA 1a) Ca2+-ATPase is a membrane protein abundantly present in
skeletal mucles where it functions as an indispensable component of the excitation …

The various splice variants of the three SERCA-and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P2A group found respectively in the membranes …