Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …

The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism (IEMs) caused by
defects in the fatty acid (FA) mitochondrial β-oxidation. The most common FAODs are …

Membrane thinning by rhomboid proteins has been proposed to reduce hydrophobic
mismatch, providing a unique environment for important functions ranging from …

Abstract γ-Secretase cleavage is essential for many biological processes and its
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …

Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (eg,
SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co …

S-acylation, whereby a fatty acid chain is covalently linked to a cysteine residue by a
thioester linkage, is the most prevalent kind of lipid modification of proteins. Thousands of …

Membranes surrounding cells or organelles represent barriers to proteins and other
molecules. However, specific proteins can cross membranes by different translocation …