The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass
V Romanello, M Sandri - Cellular and Molecular Life Sciences, 2021 - Springer
The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …
Signaling pathways that control muscle mass
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …
induced mediators of cellular attachment dynamics and extracellular matrix protein …
Role of inflammation in muscle homeostasis and myogenesis
Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …
[HTML][HTML] mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic
therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by …
therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by …
MYTHO is a novel regulator of skeletal muscle autophagy and integrity
JP Leduc-Gaudet, A Franco-Romero, M Cefis… - Nature …, 2023 - nature.com
Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …
molecular mechanisms regulating autophagy are complex and still partly understood. Here …
Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence
Muscle wasting resulting wholly or in part from disuse represents a serious medical
complication that, when prolonged, can increase morbidity and mortality. Although much …
complication that, when prolonged, can increase morbidity and mortality. Although much …
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
AL De Sousa-Coelho, PF Marrero… - Biochemical Journal, 2012 - portlandpress.com
Nutrient deprivation or starvation frequently correlates with amino acid limitation. Amino acid
starvation initiates a signal transduction cascade starting with the activation of the kinase …
starvation initiates a signal transduction cascade starting with the activation of the kinase …
The interplay between mitochondrial morphology and myomitokines in aging sarcopenia
V Romanello - International journal of molecular sciences, 2020 - mdpi.com
Sarcopenia is a chronic disease characterized by the progressive loss of skeletal muscle
mass, force, and function during aging. It is an emerging public problem associated with …
mass, force, and function during aging. It is an emerging public problem associated with …
OPA 1 deficiency promotes secretion of FGF 21 from muscle that prevents obesity and insulin resistance
RO Pereira, SM Tadinada, FM Zasadny… - The EMBO …, 2017 - embopress.org
Mitochondrial dynamics is a conserved process by which mitochondria undergo repeated
cycles of fusion and fission, leading to exchange of mitochondrial genetic content, ions …
cycles of fusion and fission, leading to exchange of mitochondrial genetic content, ions …