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Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …
The search for pain biomarkers in the human brain
Non-invasive functional brain imaging is used more than ever to investigate pain in health
and disease, with the prospect of finding new means to alleviate pain and improve patient …
and disease, with the prospect of finding new means to alleviate pain and improve patient …
Pain matrices and neuropathic pain matrices: a review
The pain matrix is conceptualised here as a fluid system composed of several interacting
networks. A nociceptive matrix receiving spinothalamic projections (mainly posterior …
networks. A nociceptive matrix receiving spinothalamic projections (mainly posterior …
The pain matrix reloaded: a salience detection system for the body
Neuroimaging and neurophysiological studies have shown that nociceptive stimuli elicit
responses in an extensive cortical network including somatosensory, insular and cingulate …
responses in an extensive cortical network including somatosensory, insular and cingulate …
Assessing pain objectively: the use of physiological markers
R Cowen, MK Stasiowska, H Laycock, C Bantel - Anaesthesia, 2015 - Wiley Online Library
Pain diagnosis and management would benefit from the development of objective markers
of nociception and pain. Current research addressing this issue has focused on five main …
of nociception and pain. Current research addressing this issue has focused on five main …
From the neuromatrix to the pain matrix (and back)
Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain
perception in humans, a large number of investigators apply noxious stimuli to the body of …
perception in humans, a large number of investigators apply noxious stimuli to the body of …
A multisensory investigation of the functional significance of the “pain matrix”
Functional neuroimaging studies in humans have shown that nociceptive stimuli elicit
activity in a wide network of cortical areas commonly labeled as the “pain matrix” and …
activity in a wide network of cortical areas commonly labeled as the “pain matrix” and …
Why fish do not feel pain
Only humans can report feeling pain. In contrast, pain in animals is typically inferred on the
basis of nonverbal behaviour. Unfortunately, these behavioural data can be problematic …
basis of nonverbal behaviour. Unfortunately, these behavioural data can be problematic …
A neurocognitive model of attention to pain: behavioral and neuroimaging evidence
The perception of pain is the result of a complex dynamic system that codes, transports and
processes nociceptive signals. The relationship between nociceptive information and pain is …
processes nociceptive signals. The relationship between nociceptive information and pain is …
Localization of pain‐related brain activation: A meta‐analysis of neuroimaging data
A meta‐analysis of 140 neuroimaging studies was performed using the activation‐likelihood‐
estimate (ALE) method to explore the location and extent of activation in the brain in …
estimate (ALE) method to explore the location and extent of activation in the brain in …