Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to
RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts …

Astrocytes represent central regulators of brain glucose metabolism and neuronal function.
They have recently been shown to adapt their function in response to alterations in …

Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic
glycolysis, is extensively found in various cancers. Interestingly, increasing researchers …

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

Atherosclerosis, an immunoinflammatory disease of medium and large arteries, is
associated with life-threatening clinical events, such as acute coronary syndromes and …

Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary
vascular remodeling leading to right heart failure and death. To date, despite the three …

Mitochondria are cellular power stations and essential organelles for maintaining cellular
homeostasis. Dysfunctional mitochondria have emerged as a key factor in the occurrence …

Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction.
There are no data from living patients to inform whether differential gene expression of …