[HTML][HTML] Improving immunovirotherapies: the intersection of mathematical modelling and experiments

CE Engeland, JPW Heidbuechel, RP Araujo… - ImmunoInformatics, 2022 - Elsevier
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols
represent a promising treatment strategy for a range of cancers and offer many advantages …

Distributed adaptive search in T cells: lessons from ants

ME Moses, JL Cannon, DM Gordon… - Frontiers in …, 2019 - frontiersin.org
There are striking similarities between the strategies ant colonies use to forage for food and
immune systems use to search for pathogens. Searchers (ants and cells) use the …

Oscillations in a spatial oncolytic virus model

AA Baabdulla, T Hillen - Bulletin of Mathematical Biology, 2024 - Springer
Virotherapy treatment is a new and promising target therapy that selectively attacks cancer
cells without harming normal cells. Mathematical models of oncolytic viruses have shown …

A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy

W Sung, C Grassberger, AL McNamara, L Basler… - Radiotherapy and …, 2020 - Elsevier
Purpose The impact of radiation therapy on the immune system has recently gained
attention particularly when delivered in combination with immunotherapy. However, it is …

Tumour-associated macrophages and oncolytic virotherapies: a mathematical investigation into a complex dynamics

R Eftimie, G Eftimie - Letters in Biomathematics, 2018 - discovery.dundee.ac.uk
Anti-cancer therapies based on oncolytic viruses are emerging as important approaches in
cancer treatment. However, the effectiveness of these therapies depends significantly on the …

Chaos and multistability behaviors in 4D dissipative cancer growth/decay model with unstable line of equilibria

PP Singh, BK Roy - Chaos, Solitons & Fractals, 2022 - Elsevier
The objective of this paper is to study the chaos and multistability behaviors in a 4D
dissipative chaotic cancer growth/decay model. The 4D chaotic cancer growth/decay model …

[HTML][HTML] Mathematical modeling of oncolytic virus therapy reveals role of the immune response

E Guo, HM Dobrovolny - Viruses, 2023 - mdpi.com
Oncolytic adenoviruses (OAds) present a promising path for cancer treatment due to their
selectivity in infecting and lysing tumor cells and their ability to stimulate the immune …

[HTML][HTML] A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept

KJ Mahasa, R Ouifki, A Eladdadi… - Mathematical …, 2022 - aimspress.com
Combining chimeric antigen receptor T (CAR-T) cells with oncolytic viruses (OVs) has
recently emerged as a promising treatment approach in preclinical studies that aim to …

Stochastic dynamics of nonlinear tumor–immune system with chemotherapy

I Bashkirtseva, A Chukhareva, L Ryashko - Physica A: Statistical Mechanics …, 2023 - Elsevier
Motivated by important applications to the solution of the problem of studying the
mechanisms of tumor treatment, we consider a model of the dynamic interaction of tumor …

Oncolytic viral therapies and the delicate balance between virus-macrophage-tumour interactions: A mathematical approach

N Almuallem, D Trucu, R Eftimie - Mathematical …, 2021 - discovery.dundee.ac.uk
The success of oncolytic virotherapies depends on the tumour microenvironment, which
contains a large number of infiltrating immune cells. In this theoretical study, we derive an …