The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …

Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

The past twenty-five years have seen a strong increase in the number of publications related
to criticality in different areas of neuroscience. The potential of criticality to explain various …

Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Evoked potentials provide valuable insight into brain processes that are integral to our ability
to interact effectively and efficiently in the world. The mismatch negativity (MMN) component …

Psychiatry faces fundamental challenges with regard to mechanistically guided differential
diagnosis, as well as prediction of clinical trajectories and treatment response of individual …

The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …