Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms
Background: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain
fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) …
fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) …
Amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review
D Allan Butterfield - Free radical research, 2002 - Taylor & Francis
Oxidative stress, manifested by protein oxidation, lipid peroxidation, DNA oxidation and 3-
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …
Atomic structures of amyloid cross-β spines reveal varied steric zippers
MR Sawaya, S Sambashivan, R Nelson, MI Ivanova… - Nature, 2007 - nature.com
Amyloid fibrils formed from different proteins, each associated with a particular disease,
contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming …
contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming …
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
SL Bernstein, NF Dupuis, ND Lazo, T Wyttenbach… - Nature …, 2009 - nature.com
In recent years, small protein oligomers have been implicated in the aetiology of a number of
important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's …
important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's …
Experimental constraints on quaternary structure in Alzheimer's β-amyloid fibrils
AT Petkova, WM Yau, R Tycko - Biochemistry, 2006 - ACS Publications
We describe solid-state nuclear magnetic resonance (NMR) measurements on fibrils formed
by the 40-residue β-amyloid peptide associated with Alzheimer's disease (Aβ1-40) that …
by the 40-residue β-amyloid peptide associated with Alzheimer's disease (Aβ1-40) that …
Amyloid-β aggregation
VH Finder, R Glockshuber - Neurodegenerative Diseases, 2007 - karger.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing
population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of …
population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of …
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer's disease
Pioneering work in the 1950s by Christian Anfinsen on the folding of ribonuclease has
shown that the primary structure of a protein “encodes” all of the information necessary for a …
shown that the primary structure of a protein “encodes” all of the information necessary for a …
Amyloid β-protein oligomers and Alzheimer's disease
EY Hayden, DB Teplow - Alzheimer's research & therapy, 2013 - Springer
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
Alzheimer's disease (AD) is a complex age‐related neurodegenerative disease. In this
review, we carefully detail amyloid‐β metabolism and its role in AD. We also consider the …
review, we carefully detail amyloid‐β metabolism and its role in AD. We also consider the …
Oxidative stress: glutathione and its potential to protect Methionine-35 of Aβ peptide from oxidation
Alzheimer's disease (AD) is the most common neurodegenerative disorder with
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …
heterogeneous etiology. Intracellular neurofibrillary tangles caused by tau (τ) protein …