Causal map** of human brain function

SH Siddiqi, KP Kording, J Parvizi, MD Fox - Nature reviews …, 2022 - nature.com
Map** human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Stanford neuromodulation therapy (SNT): a double-blind randomized controlled trial

EJ Cole, AL Phillips, BS Bentzley… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Depression is the leading cause of disability worldwide, and half of patients with
depression have treatment-resistant depression. Intermittent theta-burst stimulation (iTBS) is …

Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

SH Siddiqi, FL Schaper, A Horn, J Hsu… - Nature human …, 2021 - nature.com
Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

Functional neuroimaging in psychiatry and the case for failing better

MM Nour, Y Liu, RJ Dolan - Neuron, 2022 - cell.com
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Using brain imaging to improve spatial targeting of transcranial magnetic stimulation for depression

RFH Cash, A Weigand, A Zalesky, SH Siddiqi… - Biological …, 2021 - Elsevier
Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is
limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a …

Personalized connectivity‐guided DLPFC‐TMS for depression: Advancing computational feasibility, precision and reproducibility

RFH Cash, L Cocchi, J Lv, Y Wu… - Human brain …, 2021 - Wiley Online Library
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex
(DLPFC) is an established treatment for refractory depression, however, therapeutic …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Synaptic mechanisms regulating mood state transitions in depression

PK Parekh, SB Johnson, C Liston - Annual Review of …, 2022 - annualreviews.org
Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Functional connectivity map** for rTMS target selection in depression

IG Elbau, CJ Lynch, J Downar… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use
subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize …