Intrinsically disordered regions are poised to act as sensors of cellular chemistry

D Moses, GM Ginell, AS Holehouse… - Trends in biochemical …, 2023 - cell.com
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …

Phase separation in fungi

MI Staples, C Frazer, NL Fawzi, RJ Bennett - Nature microbiology, 2023 - nature.com
Phase separation, in which macromolecules partition into a concentrated phase that is
immiscible with a dilute phase, is involved with fundamental cellular processes across the …

Biomolecular condensates regulate cellular electrochemical equilibria

Y Dai, Z Zhou, W Yu, Y Ma, K Kim, N Rivera… - Cell, 2024 - cell.com
Control of the electrochemical environment in living cells is typically attributed to ion
channels. Here, we show that the formation of biomolecular condensates can modulate the …

Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism

CT Supuran - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
While the carbonic anhydrase (CA, EC 4.2. 1.1) superfamily of enzymes has been described
primarily as involved only in pH regulation for decades, it also has many other important …

Recent advances in optical gas sensors for carbon dioxide detection

P Li, J Li, S Song, J Chen, N Zhong, Q **e, Y Liu… - Measurement, 2024 - Elsevier
Carbon dioxide (CO 2) is a colorless and odorless gas. The imbalanced CO 2
concentrations can have detrimental effects, therefore numerous CO 2 gas sensors have …

[HTML][HTML] The adenomatous polyposis coli protein 30 years on

J Abbott, IS Näthke - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were
discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the …

Integrative regulatory mechanisms of stomatal movements under changing climate

J Zhang, X Chen, Y Song… - Journal of Integrative Plant …, 2024 - Wiley Online Library
Global climate change‐caused drought stress, high temperatures and other extreme
weather profoundly impact plant growth and development, restricting sustainable crop …

White-opaque switching in Candida albicans: cell biology, regulation, and function

DR Soll - Microbiology and Molecular Biology Reviews, 2024 - Am Soc Microbiol
Candida albicans remains a major fungal pathogen colonizing humans and
opportunistically invading tissue when conditions are predisposing. Part of the success of C …

[HTML][HTML] Study liquid–liquid phase separation with optical microscopy: A methodology review

X Zhang, H Li, Y Ma, D Zhong, S Hou - APL bioengineering, 2023 - pubs.aip.org
Intracellular liquid–liquid phase separation (LLPS) is a critical process involving the dynamic
association of biomolecules and the formation of non-membrane compartments, playing a …

Liquid-liquid phase separation: a new perspective on respiratory diseases

L Wang, Y Wang, Z Ke, Z Wang, Y Guo… - Frontiers in …, 2024 - frontiersin.org
Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating
signal transduction by creating a condensed, membrane-less environment that plays crucial …