Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …

Claudins are tetraspan transmembrane proteins of tight junctions. They determine the
barrier properties of this type of cell–cell contact existing between the plasma membranes of …

Classical cadherins are the key molecules that control cell–cell adhesion. Notwithstanding
this function, it is also clear that classical cadherins are more than just the “glue” that keeps …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of∼ 40 kd that was
originally identified as a marker for carcinoma, attributable to its high expression on rapidly …

As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are
well known as functioning as a control for the paracellular diffusion of ions and certain …

The tight junction proteins claudins are abnormally regulated in several human cancers. In
particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias …

Disruption of the cell-cell junction with concomitant changes in the expression of junctional
proteins is a hallmark of cancer cell invasion and metastasis. The role of adherent junction …

Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-
associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the …