Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Aducanumab is a monoclonal antibody selective for amyloid β (Aβ) aggregates. In June
2021, aducanumab became the first drug underlying the pathophysiology of Alzheimer's …

Alzheimer Disease (AD) is a neurodegenerative disease characterized by two
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

Alzheimer's disease is characterized by the accumulation of amyloid plaques and
neurofibrillary tangles in the brain. However, emerging evidence suggests that …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

For decades, it has been widely believed that the blood–brain barrier (BBB) provides an
immune privileged environment in the central nervous system (CNS) by blocking peripheral …

Highlights•Aβ 1− 42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …