Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Pathological mechanisms in progressive multiple sclerosis

DH Mahad, BD Trapp, H Lassmann - The Lancet Neurology, 2015 - thelancet.com
A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis

S Meier, EAJ Willemse, S Schaedelin… - JAMA …, 2023 - jamanetwork.com
Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

The cerebrospinal fluid in multiple sclerosis

F Deisenhammer, H Zetterberg, B Fitzner… - Frontiers in …, 2019 - frontiersin.org
Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four‐year study

S Saidha, O Al‐Louzi, JN Ratchford… - Annals of …, 2015 - Wiley Online Library
Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …

Identifying the distinct cognitive phenotypes in multiple sclerosis

E De Meo, E Portaccio, A Giorgio, L Ruano… - JAMA …, 2021 - jamanetwork.com
Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

The right to sexuality, reproductive health, and found a family for people with intellectual disability: A systematic review

P Perez-Curiel, E Vicente, ML Moran… - International Journal of …, 2023 - mdpi.com
Although sexuality, reproductive health, and starting a family are human rights that should
be guaranteed for all citizens, they are still taboo issues for people with intellectual disability …

Neuropsychiatric symptoms of multiple sclerosis: state of the art

C Silveira, R Guedes, D Maia, R Curral… - Psychiatry …, 2019 - pmc.ncbi.nlm.nih.gov
Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric
manifestations have a high prevalence in MS patients and may worsen the illness …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …