Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C (high) monocytes
Tumor-associated macrophages (TAM) form a major component of the tumor stroma.
However, important concepts such as TAM heterogeneity and the nature of the monocytic …
However, important concepts such as TAM heterogeneity and the nature of the monocytic …
Ecto‐calreticulin in immunogenic chemotherapy
The conventional treatment of cancer relies upon radiotherapy and chemotherapy. Such
treatments supposedly mediate their effects via the direct elimination of tumor cells …
treatments supposedly mediate their effects via the direct elimination of tumor cells …
[HTML][HTML] Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells
YY Wang, C Attané, D Milhas, B Dirat, S Dauvillier… - JCI insight, 2017 - ncbi.nlm.nih.gov
In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content
observed both in vitro and in human tumors. The free fatty acids (FFAs), released by …
observed both in vitro and in human tumors. The free fatty acids (FFAs), released by …
Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression
During progression from single cancer cells to a tumor mass and metastases, tumor cells
send signals that can subvert their tissue microenvironment. These signals involve soluble …
send signals that can subvert their tissue microenvironment. These signals involve soluble …
CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific …
Purpose: We have shown previously that the MHC class II–negative murine TS/A
adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by …
adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by …
In vitro and in vivo evaluation of ruthenium (II)− arene PTA complexes
C Scolaro, A Bergamo, L Brescacin… - Journal of medicinal …, 2005 - ACS Publications
The antitumor activity of the organometallic ruthenium (II)− arene complexes, RuCl2 (η6-
arene)(PTA),(arene= p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2, 3 …
arene)(PTA),(arene= p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2, 3 …
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents
currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as …
currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as …
High-dose vitamin C enhances cancer immunotherapy
Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …
Redirecting In vivo Elicited Tumor Infiltrating Macrophages and Dendritic Cells towards Tumor Rejection
A hostile tumor microenvironment interferes with the development and function of the
adaptive immune response. Here we report the mechanisms by which large numbers of …
adaptive immune response. Here we report the mechanisms by which large numbers of …