Non-genomic signaling of steroid receptors in cancer
C Thiebaut, V Vlaeminck-Guillem, O Trédan… - Molecular and Cellular …, 2021 - Elsevier
Steroid receptors (SRs) are members of the nuclear receptor family, which are ligand-
activated transcription factors. SRs regulate many physiological functions including …
activated transcription factors. SRs regulate many physiological functions including …
[HTML][HTML] ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
PV Elizalde, RIC Russo, MF Chervo… - Endocrine-related …, 2016 - erc.bioscientifica.com
Approximately 15–20% of breast cancers (BC) show either membrane overexpression of
ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 …
ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 …
Molecular determinants of context-dependent progesterone receptor action in breast cancer
CR Hagan, CA Lange - BMC medicine, 2014 - Springer
The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone
receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects …
receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects …
Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis
Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a
clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence …
clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence …
Molecular mechanisms underlying progesterone receptor action in breast cancer: Insights into cell proliferation and stem cell regulation
ME Cenciarini, CJ Proietti - Steroids, 2019 - Elsevier
The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …
[HTML][HTML] Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance
CY Wei, QX Tan, X Zhu, QH Qin, FB Zhu… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Background: A new diagnostic and prognostic biomarker may be of value in cancer
diseases. Our study aimed to evaluate the CDKN1A/p21 and TGFBR2 level measurable in a …
diseases. Our study aimed to evaluate the CDKN1A/p21 and TGFBR2 level measurable in a …
Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and
progesterone receptors and the lack of membrane overexpression or gene amplification of …
progesterone receptors and the lack of membrane overexpression or gene amplification of …
Fertility drugs and cancer: a guideline
Practice Committee of the American Society for … - Fertility and sterility, 2024 - Elsevier
Methodological limitations in studying the association between the use of fertility drugs and
cancer include the inherent increased risk of cancer in women who never conceive, the …
cancer include the inherent increased risk of cancer in women who never conceive, the …
Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models
Estrogen is the major mitogenic stimulus of mammary gland development during puberty
wherein ER signaling acts to induce abundant PR expression. PR signaling, in contrast, is …
wherein ER signaling acts to induce abundant PR expression. PR signaling, in contrast, is …
Increased expression of senescence markers p14ARF and p16INK4a in breast cancer is associated with an increased risk of disease recurrence and poor survival …
R Pare, JS Shin, CS Lee - Histopathology, 2016 - Wiley Online Library
Aims Breast cancer is a hormonally driven disease. Cellular senescence is an age‐related
irreversible cell cycle arrest at the G1 phase upon induction. The aim of this study was to …
irreversible cell cycle arrest at the G1 phase upon induction. The aim of this study was to …