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Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …
and are a vital part of the innate immune system for host defense against many pathogens …
Two years into the COVID-19 pandemic: lessons learned
SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of …
E Avolio, M Carrabba, R Milligan… - Clinical …, 2021 - portlandpress.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range
of clinical responses including prominent microvascular damage. The capacity of SARS …
of clinical responses including prominent microvascular damage. The capacity of SARS …
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
S Liang, C Bao, Z Yang, S Liu, Y Sun, W Cao… - … and Targeted Therapy, 2023 - nature.com
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2
virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator …
virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator …
[HTML][HTML] SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance
RR Nascimento, CC Aquino, JK Sousa, KL Gadelha… - Mucosal …, 2024 - Elsevier
Studies have reported the occurrence of gastrointestinal (GI) symptoms, primarily diarrhea,
in COVID-19. However, the pathobiology regarding COVID-19 in the GI tract remains limited …
in COVID-19. However, the pathobiology regarding COVID-19 in the GI tract remains limited …
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes
FM Zeng, Y Li, Z Deng, J He, W Li, L Wang… - EMBO molecular …, 2022 - embopress.org
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) can cause
gastrointestinal (GI) symptoms that often correlate with the severity of COVID‐19. Here, we …
gastrointestinal (GI) symptoms that often correlate with the severity of COVID‐19. Here, we …
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19
NL Lartey, S Valle-Reyes… - Journal of leukocyte …, 2022 - academic.oup.com
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by lung injury,
cytokine storm, and increased neutrophil-to-lymphocyte ratio (NLR). Current therapies focus …
cytokine storm, and increased neutrophil-to-lymphocyte ratio (NLR). Current therapies focus …
[HTML][HTML] LAIR-1 limits macrophage activation in acute inflammatory lung injury
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious health
problems that manifest as acute respiratory failure in response to different conditions …
problems that manifest as acute respiratory failure in response to different conditions …
Changes in symptoms experienced by SARS-CoV-2-infected individuals–from the first wave to the omicron variant
H Schulze, W Bayer - Frontiers in Virology, 2022 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic and public health crisis since the beginning of 2020. First recognized for the …
pandemic and public health crisis since the beginning of 2020. First recognized for the …
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and va**
Background Knowledge of the entry receptors responsible for SARS-CoV-2 is key to
understand the neural transmission and pathogenesis of COVID-19 characterized by a …
understand the neural transmission and pathogenesis of COVID-19 characterized by a …