Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - Signal transduction and …, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of …

E Avolio, M Carrabba, R Milligan… - Clinical …, 2021 - portlandpress.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range
of clinical responses including prominent microvascular damage. The capacity of SARS …

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

S Liang, C Bao, Z Yang, S Liu, Y Sun, W Cao… - … and Targeted Therapy, 2023 - nature.com
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2
virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator …

[HTML][HTML] SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance

RR Nascimento, CC Aquino, JK Sousa, KL Gadelha… - Mucosal …, 2024 - Elsevier
Studies have reported the occurrence of gastrointestinal (GI) symptoms, primarily diarrhea,
in COVID-19. However, the pathobiology regarding COVID-19 in the GI tract remains limited …

SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes

FM Zeng, Y Li, Z Deng, J He, W Li, L Wang… - EMBO molecular …, 2022 - embopress.org
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) can cause
gastrointestinal (GI) symptoms that often correlate with the severity of COVID‐19. Here, we …

ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19

NL Lartey, S Valle-Reyes… - Journal of leukocyte …, 2022 - academic.oup.com
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by lung injury,
cytokine storm, and increased neutrophil-to-lymphocyte ratio (NLR). Current therapies focus …

[HTML][HTML] LAIR-1 limits macrophage activation in acute inflammatory lung injury

DG Helou, C Quach, BP Hurrell, X Li, M Li, A Akbari… - Mucosal …, 2023 - Elsevier
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious health
problems that manifest as acute respiratory failure in response to different conditions …

Changes in symptoms experienced by SARS-CoV-2-infected individuals–from the first wave to the omicron variant

H Schulze, W Bayer - Frontiers in Virology, 2022 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic and public health crisis since the beginning of 2020. First recognized for the …