Cancer is a leading cause of death and a major health problem worldwide. While many
effective anticancer agents are available, most drugs currently on the market are not specific …

Cancer growth, annexation, and metastatic spread are all aided by the formation of new
blood vessels (angiogenesis). The commencement of the VEGF pathway leads to signal …

A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …

Since the discovery of imatinib, the first tyrosine kinase inhibitor, in 2001, targeted therapy
has become mainstream of cancer therapeutics. Despite the advantages in efficacy and low …

It is evident that cancer is a serious disease with a growing incidence and high mortality rate.
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …

The current review outlines all possible recent synthetic platforms to quinoxaline derivatives
and the potent stimulated apoptosis mechanisms targeted by anticancer therapies. The …

Quinoxaline derivatives have been incorporated into numerous marketed drugs used for the
treatment of various diseases. Examples include glecaprevir (Mavyret), voxilaprevir (Vosevi) …

Cancer is an elaborate sequence of disease grades that include uncontrolled cell growth
and division, invasion, and metastasis. Overexpression of the epidermal growth factor …

VEGFR-2, the subtype receptor tyrosine kinase (RTK) responsible for angiogenesis, is
expressed in various cancer cells. Thus, VEGFER-2 inhibition is an efficient approach for the …

Cancer is a multifactorial disorder with extremely complex genetics and progression. The
major challenge in cancer therapy is the development of cancer resistance and relapse …