Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …
bacterial infection and induce host innate immune responses. The RLRs family comprises …
Innate immunity, inflammation, and intervention in HBV infection
Hepatitis B virus (HBV) infection is still one of the most dangerous viral illnesses. HBV infects
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
Hepatitis B functional cure and immune response
JR Zheng, ZL Wang, B Feng - Frontiers in Immunology, 2022 - frontiersin.org
Hepatitis B virus (HBV) is a hepatotropic virus, which damage to hepatocytes is not direct,
but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells …
but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells …
Transcriptional and non-transcriptional activation, posttranslational modifications, and antiviral functions of interferon regulatory factor 3 and viral antagonism by the …
A Glanz, S Chakravarty, M Varghese, A Kottapalli… - Viruses, 2021 - mdpi.com
The immune system defends against invading pathogens through the rapid activation of
innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription …
innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription …
Regulation of pattern-recognition receptor signaling by HBX during hepatitis B virus infection
H You, S Qin, F Zhang, W Hu, X Li, D Liu… - Frontiers in …, 2022 - frontiersin.org
As a small DNA virus, hepatitis B virus (HBV) plays a pivotal role in the development of
various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules …
various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules …
Unraveling the multifaceted nature of CD8 T cell exhaustion provides the molecular basis for therapeutic T cell reconstitution in chronic hepatitis B and C
In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+
T cells toward a peculiar differentiation state known as T cell exhaustion, which poses …
T cells toward a peculiar differentiation state known as T cell exhaustion, which poses …
Potential antiviral activities of chrysin against hepatitis B virus
Background Interferon and nucleos (t) ide analogues are current therapeutic treatments for
chronic Hepatitis B virus (HBV) infection with the limitations of a functional cure. Chrysin (5, 7 …
chronic Hepatitis B virus (HBV) infection with the limitations of a functional cure. Chrysin (5, 7 …
Innate immunity and HBV persistence
Hepatitis B virus (HBV) causes chronic infections that are associated with immune
dysfunction. Though T cell impairment is perhaps the most prominent immune change …
dysfunction. Though T cell impairment is perhaps the most prominent immune change …
Immune mechanisms underlying hepatitis b surface antigen seroclearance in chronic hepatitis b patients with viral coinfection
S Wu, W Yi, Y Gao, W Deng, X Bi, Y Lin… - Frontiers in …, 2022 - frontiersin.org
It is considered that chronic hepatitis B patients have obtained functional cure if they get
hepatitis B surface antigen (HBsAg) seroclearance after treatment. Serum HBsAg is …
hepatitis B surface antigen (HBsAg) seroclearance after treatment. Serum HBsAg is …
The emerging role of DEAD/H-box helicases in hepatitis B virus infection
H You, L Ma, X Wang, F Zhang, Y Han, J Yao… - Frontiers in Cellular …, 2022 - frontiersin.org
DEAD/H-box helicases are an essential protein family with a conserved motif containing
unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that …
unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that …