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Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …
bacterial infection and induce host innate immune responses. The RLRs family comprises …
[HTML][HTML] Innate immunity, inflammation, and intervention in HBV infection
Hepatitis B virus (HBV) infection is still one of the most dangerous viral illnesses. HBV infects
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
Hepatitis B functional cure and immune response
JR Zheng, ZL Wang, B Feng - Frontiers in Immunology, 2022 - frontiersin.org
Hepatitis B virus (HBV) is a hepatotropic virus, which damage to hepatocytes is not direct,
but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells …
but through the immune system. HBV specific CD4+ T cells can induce HBV specific B cells …
Transcriptional and non-transcriptional activation, posttranslational modifications, and antiviral functions of interferon regulatory factor 3 and viral antagonism by the …
A Glanz, S Chakravarty, M Varghese, A Kottapalli… - Viruses, 2021 - mdpi.com
The immune system defends against invading pathogens through the rapid activation of
innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription …
innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription …
An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity
L Tang, S Remiszewski, A Snedeker, LW Chiang… - Antiviral Research, 2024 - Elsevier
Abstract 296 million people worldwide are predisposed to develo** severe end-stage liver
diseases due to chronic hepatitis B virus (HBV) infection. HBV forms covalently closed …
diseases due to chronic hepatitis B virus (HBV) infection. HBV forms covalently closed …
Hepatocyte intrinsic innate antiviral immunity against hepatitis delta virus infection: the voices of bona fide human hepatocytes
Y Woo, M Ma, M Okawa, T Saito - Viruses, 2024 - mdpi.com
The pathogenesis of viral infection is attributed to two folds: intrinsic cell death pathway
activation due to the viral cytopathic effect, and immune-mediated extrinsic cellular injuries …
activation due to the viral cytopathic effect, and immune-mediated extrinsic cellular injuries …
Potential antiviral activities of chrysin against hepatitis B virus
Background Interferon and nucleos (t) ide analogues are current therapeutic treatments for
chronic Hepatitis B virus (HBV) infection with the limitations of a functional cure. Chrysin (5, 7 …
chronic Hepatitis B virus (HBV) infection with the limitations of a functional cure. Chrysin (5, 7 …
Regulation of pattern-recognition receptor signaling by HBX during hepatitis B virus infection
H You, S Qin, F Zhang, W Hu, X Li, D Liu… - Frontiers in …, 2022 - frontiersin.org
As a small DNA virus, hepatitis B virus (HBV) plays a pivotal role in the development of
various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules …
various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules …
ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-catenin/PD-L1 axis
R Deng, R Tian, X Li, Y Xu, Y Li, X Wang, H Li, L Wang… - Iscience, 2024 - cell.com
Hepatitis B virus (HBV) infection generally elicits weak type-I interferon (IFN) immune
response in hepatocytes, covering the regulatory effect of IFN-stimulated genes. In this …
response in hepatocytes, covering the regulatory effect of IFN-stimulated genes. In this …
Immune mechanisms underlying hepatitis b surface antigen seroclearance in chronic hepatitis b patients with viral coinfection
S Wu, W Yi, Y Gao, W Deng, X Bi, Y Lin… - Frontiers in …, 2022 - frontiersin.org
It is considered that chronic hepatitis B patients have obtained functional cure if they get
hepatitis B surface antigen (HBsAg) seroclearance after treatment. Serum HBsAg is …
hepatitis B surface antigen (HBsAg) seroclearance after treatment. Serum HBsAg is …