Optimization of culture condition for Spodoptera frugiperda by design of experiment approach and evaluation of its effect on the expression of hemagglutinin protein …

F Alizadeh, H Aghajani, F Mahboudi, Y Talebkhan… - Plos one, 2024‏ - journals.plos.org
The baculovirus expression vector system (BEVS) is a powerful tool in pharmaceutical
biotechnology to infect insect cells and produce the recombinant proteins of interest. It has …

Single and multi-objective dynamic optimization study of an industrial scale fed batch reactor

B Patidar, N Padhiyar - International Journal of Chemical Reactor …, 2023‏ - degruyter.com
The present work focuses on obtaining optimal operational policies of an industrial scale
penicillin fed-batch fermentation process using dynamic optimization (DO). The three …

Advanced modeling of pharmaceutical solubility in solvents using artificial intelligence techniques: assessment of drug candidate for nanonization processing

T Al Hagbani, S Alshehri, S Bawazeer - Frontiers in Medicine, 2024‏ - frontiersin.org
This research is an analysis of multiple regression models developed for predicting
ketoprofen solubility in supercritical carbon dioxide under different levels of T (K) and P (bar) …

In‐Silico Optimization of a Bi‐Enzymatic Reactor for Mannitol Production Using Pareto‐Optimal Fronts

CL Gijiu, G Maria, L Renea - Chemical Engineering & …, 2025‏ - Wiley Online Library
For multi‐enzymatic cases, the determination of the batch reactor (BR) optimal operating
policy often translates into a difficult multi‐objective problem. Exemplification is made here …

Physics Informed Neural Networks for Baculovirus-Insect Cell System

VS Masampally, S Sharma, L Giri… - 2023 Ninth Indian …, 2023‏ - ieeexplore.ieee.org
The Baculovirus expression vector system (BEVS) is one of the widely utilized platforms for
the development of recombinant proteins, virus-like particles (VLPs), and vaccines. A …