Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …
important role in both development and cancer progression. Depending on the contextual …
Non-redundant functions of EMT transcription factors
MP Stemmler, RL Eccles, S Brabletz, T Brabletz - Nature cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
EMT factors and metabolic pathways in cancer
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
Oncogenic roles of EMT-inducing transcription factors
A Puisieux, T Brabletz, J Caramel - Nature cell biology, 2014 - nature.com
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …
Signaling mechanisms of the epithelial-mesenchymal transition
DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …
development and tissue repair. EMT also contributes to the progression of disease …
The basics of epithelial-mesenchymal transition
The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …
Epithelial-mesenchymal transitions: insights from development
Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that
occurs during development and is essential for sha** embryos. Also implicated in cancer …
occurs during development and is essential for sha** embryos. Also implicated in cancer …
Transcriptional regulation of EMT transcription factors in cancer
M Saitoh - Seminars in Cancer Biology, 2023 - Elsevier
The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
J Yang, RA Weinberg - Developmental cell, 2008 - cell.com
The epithelial-mesenchymal transition is a highly conserved cellular program that allows
polarized, immotile epithelial cells to convert to motile mesenchymal cells. This important …
polarized, immotile epithelial cells to convert to motile mesenchymal cells. This important …