Calcium (Ca2+) signals initiate egg activation across the animal kingdom and in at least
some plants. These signals are crucial for the success of development and, in the case of …

In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these
20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 …

Itch is a protective sensation that drives scratching. Although specific cell types have been
proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two …

Abstract STUDY QUESTION Are phospholipase C zeta 1 (PLCZ1) mutations associated with
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …

Abstract Changes in the intracellular concentration of free calcium (Ca 2+) underpin egg
activation and initiation of development in animals and plants. In mammals, the Ca 2+ …

During mammalian fertilization, repetitive intracellular Ca2+ increases known as Ca2+
oscillations occur. These oscillations are considered crucial for successful fertilization and …

Changes in the intracellular concentration of calcium ([Ca2+] i) represent a vital signaling
mechanism enabling communication between and among cells as well as with the …

Mammalian egg activation at fertilization is triggered by a long-lasting series of increases in
cytosolic Ca2+ concentration. These Ca2+ oscillations are due to the production of InsP3 …

About 30 years after their first observation, Ca 2+ oscillations are now recognised as a
universal mechanism of signal transduction. These oscillations are driven by periodic cycles …

Intracytoplasmic sperm injection (ICSI) is an assisted reproductive technique mainly used to
overcome severe infertility problems associated with the male factor, but in cattle its …