Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

Abstract Implication By understanding Matrix Metalloprotease (MMP) dysregulation from a
pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the
extracellular matrix. These proteinases play a central role in many biological processes …

Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with …

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the
extracellular matrix to permit normal remodeling and contribute to pathological tissue …

It is 40 years since the first member of what came to be known as the matrix
metalloproteinase (MMP) family was described. Structural, molecular and biochemical …