The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

In the last decade, inertial microfluidics has attracted significant attention and a wide variety
of channel designs that focus, concentrate and separate particles and fluids have been …

We introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical
characterization of large populations (> 100,000 cells) with analysis rates greater than 100 …

Inertial microfluidics uses the hydrodynamic effects induced at finite Reynolds numbers to
achieve passive manipulation of particles, cells, or fluids and offers the advantages of high …

Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating
at an annulus in the pipe, scientists were perplexed and spent decades learning why such …

The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …

Microfluidic detection methods for cell deformability cytometry have been regarded as
powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been …

Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …