This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They
include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing …

The mammalian hearts have the least regenerative capabilities among tissues and organs.
As such, heart regeneration has been and continues to be the ultimate goal in the treatment …

A major limitation to cardiac tissue engineering and regenerative medicine strategies is the
lack of proliferation of postnatal cardiomyocytes. The extracellular matrix (ECM) is altered …

Rationale: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac
defect. Recent studies have suggested that intracoronary administration of autologous …

Rationale: Cardiac progenitor cells are an attractive cell type for tissue regeneration, but
their mechanism for myocardial remodeling is still unclear. Objective: This investigation …

Solubilized cardiac extracellular matrix (ECM) is being developed as an injectable
therapeutic that offers promise for promoting cardiac repair. However, the ECM alone forms …

The stem cell field is hindered by its inability to noninvasively monitor transplanted cells
within the target organ in a repeatable, time-sensitive, and condition-specific manner. We …

Background: Congenital heart disease (CHD) constitutes the most prevalent and
heterogeneous group of congenital anomalies. Although surgery remains the gold standard …

Integrins are a family of heterodimeric proteins expressed by cardiac fibroblasts and
cardiomyocytes that provide critical adhesive and signaling functions through their …

Children with congenital heart diseases have increased morbidity and mortality, despite
various surgical treatments, therefore warranting better treatment strategies. Here we …