Infection-induced inflammation and cerebral injury in preterm infants

T Strunk, T Inder, X Wang, D Burgner… - The Lancet infectious …, 2014 - thelancet.com
Preterm birth and infectious diseases are the most common causes of neonatal and early
childhood deaths worldwide. The rates of preterm birth have increased over recent decades …

Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis

L Hartling, Y Liang, T Lacaze-Masmonteil - Archives of Disease in …, 2012 - fn.bmj.com
Objective To conduct a systematic review of the association between chorioamnionitis (CA)
and bronchopulmonary dysplasia (BPD) in preterm infants. Methods The authors searched …

Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury

MA Elovitz, AG Brown, K Breen, L Anton… - International Journal of …, 2011 - Elsevier
Exposure to prenatal inflammation is a known risk factor for long term neurobehavioral
disorders including cerebral palsy, schizophrenia, and autism. Models of systemic …

Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-α induction by bacterial lipopeptides …

O Levy, KA Zarember, RM Roy, C Cywes… - The Journal of …, 2004 - journals.aai.org
Newborns are at increased risk of overwhelming infection, yet the mechanisms underlying
this susceptibility are incompletely defined. In this study we report a striking 1-to 3-log …

[HTML][HTML] The elusive role of placental macrophages: the Hofbauer cell

MZ Zulu, FO Martinez, S Gordon, CM Gray - Journal of innate immunity, 2019 - karger.com
In this review, we discuss the often overlooked tissue-resident fetal macrophages, Hofbauer
cells, which are found within the chorionic villi of the human placenta. Hofbauer cells have …

Oxidative stress and bronchopulmonary dysplasia

S Perrone, ML Tataranno… - Journal of clinical …, 2012 - journals.lww.com
Bronchopulmonary dysplasia (BPD) is the major cause of pulmonary disease in infants. The
pathophysiology and management of BPD changed with the improvement of neonatal …

Placenta and fetal growth restriction

CM Salafia, AK Charles, EM Maas - Clinical obstetrics and …, 2006 - journals.lww.com
The placenta, as the vector for all maternal-fetal oxygen and nutrient exchange, is a principal
influence on birthweight. Placental weight summarizes laterally expanding growth of the …

Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?

W Thomas, CP Speer - Neonatology, 2011 - karger.com
Chorioamnionitis as a major risk factor for spontaneous preterm birth, especially at earlier
gestational ages, contributes to prematurity-associated mortality and morbidity. A gestation …

Antenatal suppression of IL-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice

M Nadeau-Vallée, PY Chin, L Belarbi… - The Journal of …, 2017 - journals.aai.org
MN-V, SP, SAR, SG, and SC designed the research studies; MN-V., P.-YC, LB, M.-ÈB, SP,
MHB, AM, AB-R., DJS, AL-M., XH, A. Boudreault, AC, IB, and SG conducted experiments; …

[HTML][HTML] Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses

BM Doratt, S Sureshchandra, H True, M Rincon… - JCI insight, 2023 - ncbi.nlm.nih.gov
Maternal SARS-CoV-2 infection triggers placental inflammation and alters cord blood
immune cell composition. However, most studies focus on outcomes of severe maternal …