Human immunodeficiency virus (HIV)
German Advisory Committee Blood … - Transfusion medicine …, 2016 - karger.com
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup 'Assessment of Pathogens
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …
Identification and specificity of broadly neutralizing antibodies against HIV
LE McCoy, DR Burton - Immunological reviews, 2017 - Wiley Online Library
Beginning in 2009, studies of the humoral responses of HIV‐positive individuals have led to
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
CXCL13 is a plasma biomarker of germinal center activity
C Havenar-Daughton, M Lindqvist… - Proceedings of the …, 2016 - National Acad Sciences
Significantly higher levels of plasma CXCL13 [chemokine (CXC motif) ligand 13] were
associated with the generation of broadly neutralizing antibodies (bnAbs) against HIV in a …
associated with the generation of broadly neutralizing antibodies (bnAbs) against HIV in a …
Cytokine-independent detection of antigen-specific germinal center T follicular helper cells in immunized nonhuman primates using a live cell activation-induced …
C Havenar-Daughton, SM Reiss… - The Journal of …, 2016 - journals.aai.org
A range of current candidate AIDS vaccine regimens are focused on generating protective
HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus macaque animal …
HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus macaque animal …
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates
A fundamental challenge in vaccinology is learning how to induce durable antibody
responses. Live viral vaccines induce antibody responses that last a lifetime, but those …
responses. Live viral vaccines induce antibody responses that last a lifetime, but those …
Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem
C Havenar‐Daughton, JH Lee… - Immunological reviews, 2017 - Wiley Online Library
The generation of HIV bnAbs may be one of the greatest feats of the human immune system
and our best hope of finally creating an HIV vaccine. The striking amount of somatic …
and our best hope of finally creating an HIV vaccine. The striking amount of somatic …
PLGA particles in immunotherapy
D Horvath, M Basler - Pharmaceutics, 2023 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) particles are a widely used and extensively studied drug
delivery system. The favorable properties of PLGA such as good bioavailability, controlled …
delivery system. The favorable properties of PLGA such as good bioavailability, controlled …
Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
Abstract The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and
recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine …
recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine …
Germinal center enhancement by extended antigen availability
KM Cirelli, S Crotty - Current opinion in immunology, 2017 - Elsevier
Highlights•Extended antigen delivery immunization results in stronger humoral immune
responses.•Germinal centers are enhanced by extended antigen delivery.•Slow antigen …
responses.•Germinal centers are enhanced by extended antigen delivery.•Slow antigen …
Virological features associated with the development of broadly neutralizing antibodies to HIV-1
The development of a preventative HIV-1 vaccine remains a global public health priority.
This will likely require the elicitation of broadly neutralizing antibodies (bNAbs) able to block …
This will likely require the elicitation of broadly neutralizing antibodies (bNAbs) able to block …