Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

Beneficial effects of dietary polyphenols on high-fat diet-induced obesity linking with modulation of gut microbiota

J Liu, Z He, N Ma, ZY Chen - Journal of Agricultural and Food …, 2019 - ACS Publications
Obesity is caused by an imbalance of energy intake and expenditure. It is characterized by a
higher accumulation of body fat with a chronic low-grade inflammation. Many reports have …

Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity

XY Zhang, J Chen, K Yi, L Peng, J **e, X Gou… - Gut …, 2020 - Taylor & Francis
Phlorizin (PHZ) is one of phytonutrients in apples that contributes to the health-promoting
effect implicated by the saying,'an apple a day keeps the doctor away'. PHZ was firstly …

Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Microbial biotransformation of bioactive flavonoids

H Cao, X Chen, AR Jassbi, J **ao - Biotechnology Advances, 2015 - Elsevier
The bioactive flavonoids are considered as the most important phytochemicals in food,
which exert a wide range of biological benefits for human being. Microbial biotransformation …

Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking

L Han, C Fang, R Zhu, Q Peng, D Li, M Wang - International Journal of …, 2017 - Elsevier
As the aglycone of phloridzin, phloretin belongs to dihydrochalcone with antioxidant, anti-
inflammatory and antimicrobial activities. In this study, multispectroscopic techniques and …

Bioaccessibility and intracellular antioxidant activity of phloretin embodied by gliadin/sodium carboxymethyl cellulose nanoparticles

JR He, JJ Zhu, SW Yin, XQ Yang - Food Hydrocolloids, 2022 - Elsevier
In this work, gliadin/sodium carboxymethyl cellulose nanoparticles (G/CMC) were prepared
to encapsulate bioactive phloretin (Phl) for improving the stability and bioaccessibility by …

Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin

KT Nakhate, H Badwaik, R Choudhary, K Sakure… - Nutrients, 2022 - mdpi.com
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio (Pistacia vera L., variety Bronte) hulls

D Barreca, G Laganà, U Leuzzi, A Smeriglio… - Food chemistry, 2016 - Elsevier
Every year tons of pistachio hulls are separated and eliminated, as waste products, from
pistachio seeds. In this study the hulls of ripe pistachios were extracted with two organic …

Antimicrobial and antioxidant activities of phenolic metabolites from flavonoid-producing yeast: Potential as natural food preservatives

KR Ng, X Lyu, R Mark, WN Chen - Food Chemistry, 2019 - Elsevier
We analysed the antimicrobial and antioxidant activities of phenolic metabolites secreted
from a naringenin-producing Saccharomyces cerevisiae strain (a GRAS organism), against …