C3-fluorinated oxindoles are important scaffolds known to demonstrate various biological
properties. As bio-isosteres of oxindoles, these compounds have shown tremendous …

Tyrosine kinase enzymes are among the primary molecular targets for the treatment of some
human neoplasms, such as those in lung cancer and chronic myeloid leukemia. Mutations in …

An efficient method for the synthesis of a new class of α-aminophosphonates of imatinib
derivative has been developed in one-pot Kabachnik-Fields reaction of N-(5-amino-2-methyl …

Chagas disease (CD) is a neglected parasitic condition endemic in the Americas caused by
Trypanosoma cruzi. Patients present an acute phase that may or not be symptomatic …

Imatinib mesylate was the first representative BCR‐ABL1 tyrosine kinase inhibitor (TKI) class
for the treatment of chronic myeloid leukemia. Despite the revolution promoted by TKIs in the …

The enzyme tyrosine kinase BCR-Abl-1 is the main molecular target in the treatment of
chronic myeloid leukemia and can be competitively inhibited by tyrosine kinase inhibitors …

Introduction: Dysregulated alternative splicing is a prominent feature of cancer. The
inhibition and knockdown of the SR splice factor kinase SRPK1 reduces tumour growth in …

Abstract Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis (1, 2, 4-
oxadiazol-3-yl) furoxan (2), and 4-amino-3-(indenotriazin-3-yl) furoxan (3)) exhibit in vitro …

Imatinib (IMT) is the first-in-class BCR-ABL commercial tyrosine kinase inhibitor (TKI).
However, the resistance and toxicity associated with the use of IMT highlight the importance …

N-(2-{[2-(1 H-Indol-2-ylcarbonyl) hydrazinyl](oxo) acetyl} phenyl) acetamides (5a–h) and N-
[2-(2-{[2-(acetylamino) phenyl](oxo) acetyl} hydrazinyl)-2-oxoethyl]-1 H-indole-2 …