The secretory capacity of a cell is constantly challenged by physiological demands and
pathological perturbations. To adjust and match the protein-folding capacity of the …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Activation of unfolded protein responses (UPRs) in cancer cells undergoing endoplasmic
reticulum (ER) stress promotes survival. However, how UPR in tumor cells impacts anti …

Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …

Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of
antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti …

Abstract Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and
oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse …

Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER)
homeostasis under adverse conditions, yet the underlying mechanisms are not well defined …