Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Hearing loss is the most common sensory disorder. While gene therapy has emerged as a
promising treatment of inherited diseases like hearing loss, it is dependent on the …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

The cochlea uses two types of mechanosensory cell to detect sounds. A single row of inner
hair cells (IHCs) synapse onto neurons to transmit sensory information to the brain, and …

Hippo signaling is an evolutionarily conserved pathway that restricts growth and
regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap …

The mammalian cochlea cannot regenerate functional hair cells (HCs) spontaneously.
Atoh1 overexpression as well as other strategies are unable to generate functional HCs …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high
percentage of the population. Currently, no approach exists to obtain large numbers of …

Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …