Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300
HJ Dyson, PE Wright - Journal of Biological Chemistry, 2016 - ASBMB
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …
particularly rich set of interactions with disordered and partly ordered partners, as a part of …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Interactions by disorder–a matter of context
Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …
interactomes of high complexity. The recent increased precision by which protein …
Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding
M Arai, K Sugase, HJ Dyson… - Proceedings of the …, 2015 - National Acad Sciences
Intrinsically disordered proteins (IDPs) frequently function in protein interaction networks that
regulate crucial cellular signaling pathways. Many IDPs undergo transitions from disordered …
regulate crucial cellular signaling pathways. Many IDPs undergo transitions from disordered …
Intrinsically disordered proteins: emerging interaction specialists
Highlights•Intrinsically disordered proteins mostly function by molecular recognition.•Post-
translational modifications regulate the interactions of IDPs.•Structural disorder can facilitate …
translational modifications regulate the interactions of IDPs.•Structural disorder can facilitate …
Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …
[HTML][HTML] On the potential of machine learning to examine the relationship between sequence, structure, dynamics and function of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
Binding mechanisms of intrinsically disordered proteins: theory, simulation, and experiment
In recent years, protein science has been revolutionized by the discovery of intrinsically
disordered proteins (IDPs). In contrast to the classical paradigm that a given protein …
disordered proteins (IDPs). In contrast to the classical paradigm that a given protein …
On the specificity of protein–protein interactions in the context of disorder
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …
interactomes, the question about their specificity—or more so on their multispecificity—arise …