It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes.
However, beige adipocytes quickly transition into white adipocytes upon removing stimuli …

Radiotherapy is pivotal in treating head and neck cancers including nasopharyngeal,
tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the …

Thermogenic beige fat found in white adipose tissue is a potential therapeutic target to curb
the global obesity and diabetes epidemic. However, these inducible thermogenic beige …

During aging and in some contexts, like embryonic development, wound healing, and
diseases such as cancer, senescent cells accumulate and play a key role in different …

Asians are more susceptible to type 2 diabetes mellitus (T2D) and its coronary heart disease
(CHD) complications than the Western populations, possibly due to genetic factors, higher …

Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin
action and secretion. Although the heritability of type 2 diabetes is high, the environment …