Molecular rotors: fluorescent sensors for microviscosity and conformation of biomolecules
The viscosity and crowding of biological environment are considered vital for the correct
cellular function, and alterations in these parameters are known to underly a number of …
cellular function, and alterations in these parameters are known to underly a number of …
[HTML][HTML] Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses
This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …
come to be recognized as fundamental organizing principle of living cells. We distinguish …
Small-molecule fluorescent probes for plasma membrane staining: Design, mechanisms and biological applications
Plasma membrane (PM), a phospholipid bilayer that separates the interior of cell from the
extracellular fluid, is closely involved in various cellular activities. However, monitoring …
extracellular fluid, is closely involved in various cellular activities. However, monitoring …
Cell surface-localized imaging and sensing
Systematically dissecting the molecular basis of the cell surface as well as its related
biological activities is considered as one of the most cutting-edge fields in fundamental …
biological activities is considered as one of the most cutting-edge fields in fundamental …
Designing a green-emitting viscosity-sensitive 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) probe for plasma membrane viscosity imaging
Viscosity is a key characteristic of lipid membranes–it governs the passive diffusion of
solutes and affects the lipid raft formation and membrane fluidity. Precise determination of …
solutes and affects the lipid raft formation and membrane fluidity. Precise determination of …
Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
A Vyšniauskas, I López-Duarte, N Duchemin… - Physical Chemistry …, 2017 - pubs.rsc.org
Microviscosity is a key parameter controlling the rate of diffusion and reactions on the
microscale. One of the most convenient tools for measuring microviscosity is by fluorescent …
microscale. One of the most convenient tools for measuring microviscosity is by fluorescent …
Directly imaging emergence of phase separation in peroxidized lipid membranes
M Paez-Perez, A Vyšniauskas, I López-Duarte… - Communications …, 2023 - nature.com
Lipid peroxidation is a process which is key in cell signaling and disease, it is exploited in
cancer therapy in the form of photodynamic therapy. The appearance of hydrophilic moieties …
cancer therapy in the form of photodynamic therapy. The appearance of hydrophilic moieties …
Cyclopropyl substituents transform the viscosity-sensitive BODIPY molecular rotor into a temperature sensor
A Vyšniauskas, B Cornell, PS Sherin… - ACS …, 2021 - ACS Publications
A quantitative fluorescent probe that responds to changes in temperature is highly desirable
for studies of biological environments, particularly in cellulo. Here, we report new cell …
for studies of biological environments, particularly in cellulo. Here, we report new cell …
The role of plasma membrane viscosity in the response and resistance of cancer cells to oxaliplatin
L Shimolina, A Gulin, N Ignatova, I Druzhkova… - Cancers, 2021 - mdpi.com
Simple Summary Understanding the role of the plasma membrane in the responses of
cancer cells to chemotherapy is important because the cell membrane is directly involved in …
cancer cells to chemotherapy is important because the cell membrane is directly involved in …
Endomembrane tension and trafficking
Eukaryotic cells employ diverse uptake mechanisms depending on their specialized
functions. While such mechanisms vary widely in their defining criteria: scale, molecular …
functions. While such mechanisms vary widely in their defining criteria: scale, molecular …