Functional analysis of GSTK1 in peroxisomal redox homeostasis in HEK-293 Cells

CF Costa, C Lismont, S Chornyi, H Li, MAF Hussein… - Antioxidants, 2023 - mdpi.com
Peroxisomes serve as important centers for cellular redox metabolism and communication.
However, fundamental gaps remain in our understanding of how the peroxisomal redox …

Enhanced Levels of Peroxisome-Derived H2O2 Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

H Li, C Lismont, CF Costa, MAF Hussein, M Baes… - Antioxidants, 2023 - mdpi.com
Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide
(H2O2)-producing and-degrading enzymes. Given that this oxidant functions as a major …

Peroxisome-derived hydrogen peroxide modulates the sulfenylation profiles of key redox signaling proteins in Flp-In T-REx 293 cells

C Lismont, I Revenco, H Li, CF Costa… - Frontiers in Cell and …, 2022 - frontiersin.org
The involvement of peroxisomes in cellular hydrogen peroxide (H2O2) metabolism has
been a central theme since their first biochemical characterization by Christian de Duve in …

The solute carrier SLC25A17 sustains peroxisomal redox homeostasis in diverse mammalian cell lines

CF Costa, C Lismont, S Chornyi, J Koster, H Li… - Free Radical Biology …, 2024 - Elsevier
Despite the crucial role of peroxisomes in cellular redox maintenance, little is known about
how these organelles transport redox metabolites across their membrane. In this study, we …

[HTML][HTML] Characterization of the Peroxisomal Proteome and Redox Balance in Human Prostate Cancer Cell Lines

MAF Hussein, C Lismont, CF Costa, H Li, F Claessens… - Antioxidants, 2024 - mdpi.com
Prostate cancer (PCa) is associated with disruptions in cellular redox balance. Given the
intricate role of peroxisomes in redox metabolism, we conducted comprehensive proteomics …

PEX14 functions as a molecular link between optineurin and pexophagy in human cells

H Li, S Chen, C Lismont, B Vandewinkel, MAF Hussein… - bioRxiv, 2024 - biorxiv.org
Pexophagy, the selective degradation of peroxisomes, is essential for removing excess or
dysfunctional peroxisomes, and its dysregulation is linked to various diseases. Previous …

Polyphenols and novel insights into post-kidney transplant complications and cardiovascular disease: a narrative review

NI Bustos, CG Sotomayor, RA Pol, GJ Navis… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation is the preferred treatment for end-stage kidney disease. It is,
however, not devoid of complications. Delayed graft function related to ischemia-reperfusion …

[PDF][PDF] PEX14 functions as a molecular link between optineurin and pexophagy in human cells

H Li, S Chen, C Lismont, B Vandewinkel, M Hussein… - 2024 - lirias.kuleuven.be
Pexophagy, the selective degradation of peroxisomes, is essential for removing excess or
dysfunctional peroxisomes, and its dysregulation is linked to various diseases. Previous …

The Peroxisomal Redox Orchestra: New Melodies of Old Molecular Players

C Figueiredo Costa, M Fransen - 2023 - lirias.kuleuven.be
Eukaryotic life, viewed from a physicochemical perspective, is a remarkable phenomenon
that defies all odds, as it emerges solely through the occurrence of seemingly unfavorable …

Peroxisome-derived hydrogen peroxide can modulate the sulfenylation profiles of key redox signaling proteins

C Lismont, I Revenco, H Li, CF Costa, L Lenaerts… - BioRxiv, 2021 - biorxiv.org
Ever since the first characterization of peroxisomes, a central theme has been their
involvement in cellular hydrogen peroxide (H2O2) metabolism. While the reputation of H2O2 …