New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

[HTML][HTML] Fetal brain MRI atlases and datasets: A review

T Ciceri, L Casartelli, F Montano, S Conte, L Squarcina… - NeuroImage, 2024 - Elsevier
Fetal brain development is a complex process involving different stages of growth and
organization which are crucial for the development of brain circuits and neural connections …

Neural substrate and clinical significance of general movements: an update

M Hadders‐Algra - Developmental Medicine & Child Neurology, 2018 - Wiley Online Library
General movements are present from early fetal life to 3 to 5 months corrected age. Atypical
general movements, especially in the last, so‐called fidgety general movement phase, are …

[HTML][HTML] The enigmatic fetal subplate compartment forms an early tangential cortical nexus and provides the framework for construction of cortical connectivity

I Kostović - Progress in neurobiology, 2020 - Elsevier
The most prominent transient compartment of the primate fetal cortex is the deep, cell-
sparse, synapse-containing subplate compartment (SPC). The developmental role of the …

Neuronal impact of patient-specific aberrant NRXN1α splicing

E Flaherty, S Zhu, N Barretto, E Cheng, PJM Deans… - Nature …, 2019 - nature.com
NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions
in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human …

Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders

Z Hu, X **ao, Z Zhang, M Li - Molecular psychiatry, 2019 - nature.com
Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …

New perspective on sustained antidepressant effect: focus on neurexins regulating synaptic plasticity

Y Ruan, R Yuan, J He, Y Jiang, S Chu, N Chen - Cell Death Discovery, 2024 - nature.com
Depression is highly prevalent globally, however, currently available medications face
challenges such as low response rates and short duration of efficacy. Additionally …

Autism spectrum disorders: multiple routes to, and multiple consequences of, abnormal synaptic function and connectivity

L Carroll, S Braeutigam, JM Dawes… - The …, 2021 - journals.sagepub.com
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders of genetic and environmental etiologies. Some ASD cases are syndromic …

Effect of aging on the human myometrium at single-cell resolution

P Punzon-Jimenez, A Machado-Lopez… - Nature …, 2024 - nature.com
Age-associated myometrial dysfunction can prompt complications during pregnancy and
labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in …

Bridging the translational gap: what can synaptopathies tell us about autism?

CJ Molloy, J Cooke, NJF Gatford… - Frontiers in molecular …, 2023 - frontiersin.org
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …