Glioblastoma vaccines as promising immune-therapeutics: challenges and current status

A Squalli Houssaini, S Lamrabet, JP Nshizirungu… - Vaccines, 2024 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor. Standard
treatments including surgical resection, radiotherapy, and chemotherapy, have failed to …

H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions

LF Nonnenbroich, SM Bouchal, E Millesi… - Cells, 2024 - mdpi.com
Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their
aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered …

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

M Arafat, M Sakkal, R Beiram, S AbuRuz - Pharmaceuticals, 2024 - mdpi.com
Cancer continues to pose one of the most critical challenges in global healthcare. Despite
the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting …

Nanoencapsulation of general anaesthetics

BMT Abdoullateef, SED Al-Mofty, HME Azzazy - Nanoscale Advances, 2024 - pubs.rsc.org
General anaesthetics are routinely used to sedate patients during prolonged surgeries and
administered via intravenous injection and/or inhalation. All anaesthetics have short half …

Protein corona potentiates the recovery of nanoparticle-induced disrupted tight junctions in endothelial cells

MD Ghouri, A Tariq, J Saleem, A Muhaymin… - Nanoscale …, 2025 - pubs.rsc.org
Nanoparticle interactions with biological systems are intricate processes influenced by
various factors, among which the formation of protein corona plays a pivotal role. This …

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

S Liu, H Li, S **, Y Zhang, T Sun - International Journal of …, 2025 - Taylor & Francis
Given the complexity of the central nervous system (CNS) and the diversity of neurological
conditions, the increasing prevalence of neurological disorders poses a significant …

Non-Invasive Device-Mediated Drug Delivery to the Brain across the Blood–Brain Barrier

T Tashima, N Tournier - Pharmaceutics, 2024 - mdpi.com
We will be serving as the Guest Editor for this very interesting Special Issue on “Non-
Invasive Device-Mediated Drug Delivery to the Brain Across the Blood–Brain Barrier”. It is …

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

D Gül, B Önal Acet, Q Lu, RH Stauber… - International Journal of …, 2024 - mdpi.com
Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by
therapeutic agents and effectively overcome biological barriers. Smart designed/tuned …

[HTML][HTML] Anti-glioma effect of paclitaxel mediated by specific mode electroacupuncture stimulation and the related role of the Hedgehog pathway

C Ma, Q Ye, K Qian, M Dai, L Gan, J Yang, Z Jia… - Brain Research …, 2024 - Elsevier
Introduction Paclitaxel (PTX) cannot effectively treat glioma because it cannot cross the
bloodsingle bondbrain barrier (BBB). A specific mode electroacupuncture stimulation …

Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury

X Chen, B Wang, Y Zhou, X Wu, A Du… - Advanced …, 2024 - Wiley Online Library
Oxidative stress (OS) is one of the crucial molecular events of secondary spinal cord injury
(SCI). Basic fibroblast growth factor (bFGF) is a multipotent cell growth factor with an anti …