Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview
In aerobic bioprocesses, oxygen is a key substrate; due to its low solubility in broths
(aqueous solutions), a continuous supply is needed. The oxygen transfer rate (OTR) must be …
(aqueous solutions), a continuous supply is needed. The oxygen transfer rate (OTR) must be …
The value of natural products to future pharmaceutical discovery
DD Baker, M Chu, U Oza, V Rajgarhia - Natural product reports, 2007 - pubs.rsc.org
Covering: 2004 to 2006 Natural products have provided considerable value to the
pharmaceutical industry over the past half century. In particular, the therapeutic areas of …
pharmaceutical industry over the past half century. In particular, the therapeutic areas of …
High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection–time-of-flight mass spectrometry
Direct injection of samples on high-resolving mass spectrometers is an effective way to
maximize analytical throughput and yet allow analyte discrimination in complex samples by …
maximize analytical throughput and yet allow analyte discrimination in complex samples by …
minibioreactors
The performance of currently available minibioreactors with volumes below about 100 ml is
reviewed. Bioreactors are characterized by their area of application, by mass transfer and …
reviewed. Bioreactors are characterized by their area of application, by mass transfer and …
Metabolic engineering
J Nielsen - Applied microbiology and biotechnology, 2001 - Springer
Metabolic engineering has developed as a very powerful approach to optimising industrial
fermentation processes through the introduction of directed genetic changes using …
fermentation processes through the introduction of directed genetic changes using …
Empirical antibacterial drug discovery—Foundation in natural products
SB Singh, JF Barrett - Biochemical pharmacology, 2006 - Elsevier
Natural products have been a rich source in providing leads for the development of drugs for
the treatment of bacterial infections. However, beyond the discovery of the natural product …
the treatment of bacterial infections. However, beyond the discovery of the natural product …
Sustainable source of omega-3 eicosapentaenoic acid from metabolically engineered Yarrowia lipolytica: from fundamental research to commercial production
D **e, EN Jackson, Q Zhu - Applied microbiology and biotechnology, 2015 - Springer
The omega-3 fatty acids, cis-5, 8, 11, 14, and 17-eicosapentaenoic acid (C20: 5; EPA) and
cis-4, 7, 10, 13, 16, and 19-docosahexaenoic acid (C22: 6; DHA), have wide-ranging …
cis-4, 7, 10, 13, 16, and 19-docosahexaenoic acid (C22: 6; DHA), have wide-ranging …
Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code
A Liu, L Tran, E Becket, K Lee, L Chinn… - Antimicrobial agents …, 2010 - Am Soc Microbiol
We have defined a sensitivity profile for 22 antibiotics by extending previous work testing the
entire KEIO collection of close to 4,000 single-gene knockouts in Escherichia coli for …
entire KEIO collection of close to 4,000 single-gene knockouts in Escherichia coli for …
Evolutionary engineering of industrially important microbial phenotypes
U Sauer - Metabolic engineering, 2001 - Springer
The tremendous complexity of dynamic interactions in cellular systems often impedes
practical applications of metabolic engineering that are largely based on available …
practical applications of metabolic engineering that are largely based on available …
Miniature bioreactors: current practices and future opportunities
JI Betts, F Baganz - Microbial cell factories, 2006 - Springer
This review focuses on the emerging field of miniature bioreactors (MBRs), and examines
the way in which they are used to speed up many areas of bioprocessing. MBRs aim to …
the way in which they are used to speed up many areas of bioprocessing. MBRs aim to …