Immune memory—comprising T cells, B cells and plasma cells and their secreted antibodies—
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …

With the worldwide spread of the novel severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization …

T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent
studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1+ …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Chronic viral infections are characterized by a state of CD8+ T-cell dysfunction that is
associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor,,,. A …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Memory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces;
thus, infection detection rates depend on memory cell number and distribution. Population …