Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

In tissues, many cells are surrounded by and interact with a three-dimensional soft
extracellular matrix (ECM). Both the physical and biochemical properties of the ECM play a …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

BMMSCs have drawn great interest in tissue engineering and regenerative medicine
attributable to their multi-lineage differentiation capacity. Increasing evidence has shown …

For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix
remodeling is associated with enhanced osteogenic differentiation. However, the …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Large injuries to bones are still one of the most challenging musculoskeletal problems.
Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in …