Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
Innate immune evasion strategies of SARS-CoV-2
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
R Ahmed-Belkacem, M Hausdorff… - Journal of medicinal …, 2022 - ACS Publications
Enzymes involved in RNA cap** of SARS-CoV-2 are essential for the stability of viral
RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive …
RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive …
Coronaviral RNA-methyltransferases: function, structure and inhibition
R Nencka, J Silhan, M Klima, T Otava… - Nucleic acids …, 2022 - academic.oup.com
Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
Linking scientific instruments and computation: Patterns, technologies, and experiences
Powerful detectors at modern experimental facilities routinely collect data at multiple GB/s.
Online analysis methods are needed to enable the collection of only interesting subsets of …
Online analysis methods are needed to enable the collection of only interesting subsets of …
A comprehensive study to unleash the putative inhibitors of serotype2 of dengue virus: Insights from an in silico structure-based drug discovery
Dengue fever is a mosquito-borne disease that claims the lives of millions of people around
the world. A number of factors like disease's non-specific symptoms, increased viral …
the world. A number of factors like disease's non-specific symptoms, increased viral …
[HTML][HTML] Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39
P Skvara, D Chalupska, M Klima, J Kozic, J Silhan… - Antiviral Research, 2023 - Elsevier
Mpox is a zoonotic disease caused by the mpox virus (MPXV), which has gained attention
due to its rapid and widespread transmission, with reports from more than 100 countries …
due to its rapid and widespread transmission, with reports from more than 100 countries …
Regulation of antiviral innate immunity by chemical modification of viral RNA
N Li, TM Rana - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
More than 100 chemical modifications of RNA, termed the epitranscriptome, have been
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …