Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …

Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …

Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …

We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of
thousands of m6A residues in mammalian mRNA with single-nucleotide resolution. More …

Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …

Alternative polyadenylation (APA) is a pervasive mechanism in the regulation of most
human genes, and its implication in diseases including cancer is only beginning to be …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

The global shortening of messenger RNAs through alternative polyadenylation (APA) that
occurs during enhanced cellular proliferation represents an important, yet poorly understood …

RNA-binding proteins (RBPs) are key players in the post-transcriptional regulation of gene
expression. Precise knowledge about their binding sites is therefore critical to unravel their …