Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
The diversified role of mitochondria in ferroptosis in cancer
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …
Targeting ferroptosis in acute kidney injury
L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …
To address this problem, several therapeutic approaches have been proposed, including …
Ferroptosis in immunostimulation and immunosuppression
Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
Targeting ferroptosis: pathological mechanism and treatment of ischemia‐reperfusion injury
X Li, N Ma, J Xu, Y Zhang, P Yang, X Su… - Oxidative Medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion (I/R) is a pathological process that occurs in many organs and
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
[HTML][HTML] The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review
M Liu, XY Kong, Y Yao, XA Wang, W Yang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Methods We searched all original papers and reviews about the molecular mechanisms of
ferroptosis in antioxidant systems using PubMed to November 2021. The search terms used …
ferroptosis in antioxidant systems using PubMed to November 2021. The search terms used …
METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification
Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …