The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - Signal transduction and …, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

B Wiernicki, S Maschalidi, J Pinney, S Adjemian… - Nature …, 2022 - nature.com
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

Ferroptosis in immunostimulation and immunosuppression

D Tang, G Kroemer, R Kang - Immunological Reviews, 2024 - Wiley Online Library
Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …

Targeting ferroptosis: pathological mechanism and treatment of ischemia‐reperfusion injury

X Li, N Ma, J Xu, Y Zhang, P Yang, X Su… - Oxidative medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion (I/R) is a pathological process that occurs in many organs and
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …

The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review

M Liu, XY Kong, Y Yao, XA Wang… - Annals of …, 2022 - pmc.ncbi.nlm.nih.gov
Background and Objective Ferroptosis is a recently discovered form of cell death which
differs from other forms of cell death in terms of morphology, biochemistry, and regulatory …