Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea
M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2020 - royalsocietypublishing.org
Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …
Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period
V G. Duschak - Recent patents on anti-infective drug discovery, 2016 - benthamdirect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …
typically spread by triatomine vectors affecting millions of people all over Latin America …
[HTML][HTML] Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes
H Acosta, R Burchmore, C Naula… - Molecular and …, 2019 - Elsevier
In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis
are compartmentalized in glycosomes, which are authentic but specialized peroxisomes …
are compartmentalized in glycosomes, which are authentic but specialized peroxisomes …
Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections
M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2025 - royalsocietypublishing.org
Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic
pathways. It has great relevance at a physiological level because it is responsible for …
pathways. It has great relevance at a physiological level because it is responsible for …
Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi
Abstract Per-ARNT-Sim (PAS) domains of proteins play important roles as modules for
signalling and cellular regulation processes in widely diverse organisms such as Archaea …
signalling and cellular regulation processes in widely diverse organisms such as Archaea …
A Trypanosoma cruzi phosphoglycerate kinase isoform with a Per-Arnt-Sim domain acts as a possible sensor for intracellular conditions
M Rojas-Pirela, A Delgado… - Experimental …, 2023 - Elsevier
Abstract Per-ARNT-Sim (PAS) domains constitute a family of domains present in a wide
variety of prokaryotic and eukaryotic organisms. They form part of the structure of various …
variety of prokaryotic and eukaryotic organisms. They form part of the structure of various …
Molecular and biochemical characterization of natural and recombinant phosphoglycerate kinase B from Trypanosoma rangeli
O Villafraz, R Rondón-Mercado, AJ Cáceres… - Experimental …, 2018 - Elsevier
T. rangeli epimastigotes contain only a single detectable phosphoglycerate kinase (PGK)
enzyme in their cytosol. Analysis of this parasite's recently sequenced genome showed a …
enzyme in their cytosol. Analysis of this parasite's recently sequenced genome showed a …
[PDF][PDF] Edinburgh Infectious Diseases Annual Report 2015
R Fitzgerald, H Snaith - edwebcontent.ed.ac.uk
The mission of Edinburgh Infectious Diseases is to build a world leading consortium in
infectious disease sciences across the University of Edinburgh and neighbouring Institutions …
infectious disease sciences across the University of Edinburgh and neighbouring Institutions …